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Rhodium (II) (isobutyrate)4L2, an antitumor drug, was shown to react with nucleic acid base derivatives, A, G, U and C in chloroform solution. When these derivatives were treated with one of novel metal compounds, rhodium carboxylate in chloroform solution, a fairly strong complex formation was observed by spectroscopic techniques. The characteristic of these complex was that binding occured at the two axial positions of rhodium (II) (isobutyrate)4L2 to the NH or NH2 group of the base in the ligands.
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